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Plasma Cocaine Metabolite Levels and Liver CYP450 3A4 Isoenzyme Activity as Indicators of Cocaine Metabolism in Rats Treated With Salako Supplements

Plasma Cocaine Metabolite Levels and Liver CYP450 3A4 Isoenzyme Activity as Indicators of Cocaine Metabolism in Rats Treated With Salako Supplements
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Author(s): Natwaine Sherune Gardner (University of the West Indies, Jamaica), Kedon J. S. Luke (University of the West Indies, Jamaica), Andrew O. Wheatley (University of the West Indies, Jamaica), Winston De La Haye (University of the West Indies, Jamaica), Perceval Steven Bahado-Singh (University of Maryland Medical System, USA), Lowell L. Dilworth (University of the West Indies, Jamaica), Donovan A. McGrowder (University of the West Indies, Jamaica), Everard Barton (University of the West Indies, Jamaica), Lauriann E. Young-Martin (University of the West Indies, Jamaica), Ajibeke Salako-Akande (Getwele Natureceuticals, USA), Henry Lowe (Environmental Health Foundation, Jamaica), Errol Morrison (National Commission on Science and Technology, Jamaica), Denise Eldermire-Shearer (University of the West Indies, Jamaica)and Helen Asemota (University of the West Indies, Jamaica)
Copyright: 2019
Pages: 21
Source title: Strategic Applications of Measurement Technologies and Instrumentation
Source Author(s)/Editor(s): Soubantika Palchoudhury (University of Tennessee at Chattanooga, USA)
DOI: 10.4018/978-1-5225-5406-6.ch001

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Abstract

The effects of Salako nutritional supplements on cocaine-dependent Sprague Dawley rats was investigated. Rats were made cocaine-dependent using conditioned place preference (CPP) where craving was analyzed regularly. Cocaine metabolite levels were determined from blood samples. CYP450 3A4 isoenzyme activities were obtained using liver homogenate. Statistical analysis was done using SPSS one-way ANOVA and Duncans multiple range test. Results show that when cocaine use was discontinued, the supplements reduced craving of cocaine significantly. Blood plasma results showed higher benzoylecgonine equilibrium possibly indicating that the supplements aided the removal of stored cocaine metabolites which may have contributed to better management of craving in the rats. CYP450 3A4 isoenzyme activity was further enhanced by the supplements and is indicative of increased cocaine metabolism. The results indicate that the Salako nutritional supplements reduce craving caused by chronic cocaine administration by increasing the liver CYP450 3A4 isoenzyme activity, resulting in better plasma clearance.

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