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Pharmacology of Different Immunity Cell Components and Growth Factors: Approaches for Cancer Immunotherapy
Abstract
Tumor-associated macrophages are immune cells that regulate various factors in the tumor microenvironment and play an important role in connecting cancer with various immune cells in the tumor microenvironment. Recently, these tumor-associated macrophages have also been recognized as biomarkers for the treatment of cancer, and anti-cancer drugs have been developed targeting them. This new therapeutic approach is to achieve the effect of reprogramming immune cells to attack cancer cells by combination therapy with immune checkpoint inhibitors and a next-generation immuno-oncology drugs developed based on tumor-associated macrophages. These Chapter elaborates therapeutic strategy and development of drug targeting tumor-associated macrophages to date is limited to inhibiting the recruitment of them. Thus, in order to develop a novel development of Pharmaceutical drug delivery system like nanoparticles, etc. that encompasses the whole tumor microenvironment, particularly Evasion methodology is essentially needed with mechanisms in which macrophages regulate immunity.
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