Pharmacological Properties of Curcumin: Solid Gold or Just Pyrite?

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Author(s): Anuradha Singh (Sadanlal Sanwaldas Khanna Girls' Degree College, India & University of Allahabad, Prayagraj, India)
Copyright: 2020
Pages: 14
Source title: Advanced Pharmacological Uses of Medicinal Plants and Natural Products
Source Author(s)/Editor(s): Ajeet Singh (National Dairy Research Institute, India), Padam Singh (Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, India)and Navneet Bithel (Gurukul Kangri University, India)
DOI: 10.4018/978-1-7998-2094-9.ch012

Keywords: Medical Information Science Reference / Medicine & Healthcare / Pharmacology

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Abstract

Curcumin, the polyphenol natural product, is a constituent of the traditional medicine known as turmeric. Extensive research over the last 50 years has indicated that this polyphenol displays potent pharmacological effects by targeting many critical cellular factors through a diverse array of mechanisms of action. However, there are some obstacles that prevent this wonder molecule to be effective in clinical settings and limit its use to topical applications only. Curcumin has recently been classified as both PAINS (panassay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. Due to likely false activity of curcumin in vitro and in vivo has resulted unsuccessful clinical trial of curcumin against several disease. The chapter will review the essential medicinal chemistry of curcumin as well as envisage a compilation and discussion on the poor bioavailability of curcumin.

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Pharmacological Properties of Curcumin: Solid Gold or Just Pyrite?

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