The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
Oxidative Stress in Cardiovascular Disorders: Mechanisms and Therapeutic Implications
|
|
Author(s): Karan Goel (M.M College of Pharmacy, Maharishi Markandeshwar University (Deemed), India), Isha Chawla (M.M College of Pharmacy, Maharishi Markandeshwar University (Deemed), India), Garima Malik (Chitkara College of Pharmacy, Chitkara University, India)and Meenakshi Dhanawat (Amity Institute of Pharmacy, Amity University, India)
Copyright: 2025
Pages: 28
Source title:
The Role of Reactive Oxygen Species in Human Health and Disease
Source Author(s)/Editor(s): Pranav Kumar Prabhakar (Department of Biotechnology, Nagaland University, India)
DOI: 10.4018/979-8-3693-7919-6.ch009
Purchase
|
Abstract
Cardiovascular disorders (CVDs) include atherosclerosis, cardiac failure, hypertension, myocardial infarction, and oxidative stress, which are increasingly recognized as essential factors for the onset and advancement of these conditions. he imbalance between the formation of reactive oxygen species (ROS) and the antioxidant defense system is the molecular basis of oxidative stress, which leads to oxidative damage to lipids, proteins, and DNA. This potential damage promotes inflammatory responses, disrupts endothelial function, and speeds up atherogenesis. The nitric oxide synthase uncoupling, mitochondrial dysfunction, and NADPH-oxidizing enzymes are important pathways that enhance ROS production. Antioxidants including polyphenols, vitamins E and C, and others have shown conflicting outcomes in clinical studies. These novel methods aim to improve natural antioxidant defenses, alter redox-sensitive signaling pathways, and target specific ROS sources.
Related Content
|
Dawn Prentice.
© 2026.
10 pages.
|
|
Yumi Tamura, Yuka Murata.
© 2026.
12 pages.
|
|
Carole A. Orchard.
© 2026.
22 pages.
|
|
Katsumi Fujitani.
© 2026.
10 pages.
|
|
Jenn Salfi.
© 2026.
12 pages.
|
|
Ralph A. Gigliotti, Sara E. Spear, Christine Goldthwaite.
© 2026.
24 pages.
|
|
Risa Suzuki.
© 2026.
28 pages.
|
|
|