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Optimizing Evidence: A Deep Dive Into Randomization Techniques in Clinical Trials
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Author(s): Kazeem Adewale Osuolale (Nigerian Institute of Medical Research, Nigeria), Adesola Zaidat Musa (Nigerian Institute of Medical Research, Nigeria), Kazeem Iyanda Falade (Dangote University, Kano, Nigeria), Oluwaseun Aramide Otekunrin (University of Ibadan, Nigeria), Yusro Ayomide Osuolale (Federal University of Health Sciences, Nigeria), Dolapo Abidemi Shobanke (Federal University Lokoja, Nigeria)and Abideen Olurotimi Salako (Nigerian Institute of Medical Research, Nigeria)
Copyright: 2024
Pages: 15
Source title:
Exploring Medical Statistics: Biostatistics, Clinical Trials, and Epidemiology
Source Author(s)/Editor(s): Geeta Arora (Lovely Professional University, India), Sarabjit Singh (Punjab Institute of Medical Sciences, India)and Homan Emadifar (Islamic Azad University, Iran)
DOI: 10.4018/979-8-3693-2655-8.ch010
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Abstract
Randomization stands as a pivotal component of clinical trial methodology, ensuring unbiased treatment allocation and robust study outcomes. However, its application raises significant ethical considerations that demand careful examination to uphold research ethics and safeguard participant rights. In this study, we explore the ethical implications of randomization in clinical trials, drawing insights from original references. Through a comprehensive analysis, we delineate key ethical issues surrounding randomization, including equitable treatment allocation, informed consent, participant autonomy, and the balance between scientific rigor and participant welfare. By elucidating these ethical dimensions, this study contributes to the ongoing discourse on research ethics and underscores the importance of ethical considerations in shaping the conduct and interpretation of clinical trials.
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