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Nose-to-Brain Delivery of Nanoformulations for Treatment of Depression: Focus on Antioxidant and Anti-Inflammatory Pathways
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Author(s): Tahmineh Mokhtari (Faculty of Basic Medical Sciences, China), Fatemeh Sheikhbahaei (Kerman University of Medical Sciences, Iran), Maryam Saadat (Semnan University of Medical Sciences, Iran)and Kadir Uludag (Shanghai Mental Health Center, China)
Copyright: 2025
Pages: 30
Source title:
Nanomaterials and the Nervous System
Source Author(s)/Editor(s): Deniz Eren Erisen (Nanjing University of Aeronautics and Astronautics, China), Kadir Uludag (Shanghai Jiao Tong University, China)and Nafees Ahmad (Central South University, China)
DOI: 10.4018/979-8-3693-3065-4.ch009
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Abstract
Depression is commonly linked to heightened levels of pro-inflammatory markers, emphasizing the importance of addressing this aspect for effective treatment. Current treatment options encompass selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and bioactive compounds from herbal medicine with antidepressant properties. Nevertheless, ensuring adequate drug levels in the brain regions affected by depression poses a challenge. To surmount this obstacle, leveraging drug delivery systems capable of breaching the blood-brain barrier (BBB) has emerged as a promising strategy for administering antidepressants. Nanoformulations (NFs) have shown promise in this regard, facilitating the delivery of antidepressant agents. This examination offers an outline of nose-to-brain delivery using NFs for treating depression, with a focus on enhancing anti-inflammatory and antioxidant effects.
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