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A Model for a Heterogeneous Genetic Network

A Model for a Heterogeneous Genetic Network
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Author(s): Ângela T.F. Gonçalves (Darwin College, UK)and Ernesto J.F. Costa (Pólo II- Pinhal de Marrocos, Portugal)
Copyright: 2010
Pages: 23
Source title: Handbook of Research on Computational Methodologies in Gene Regulatory Networks
Source Author(s)/Editor(s): Sanjoy Das (Kansas State University, USA), Doina Caragea (Kansas State University, USA), Stephen Welch (Kansas State University, USA)and William H. Hsu (Kansas State University, USA)
DOI: 10.4018/978-1-60566-685-3.ch022

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Abstract

In this chapter, we propose a new model for gene regulatory networks (GRN). The model incorporates more biological detail than other approaches, and is based on an artificial genome from which several products like genes, mRNA, miRNA, noncoding RNA, and proteins are extracted and connected, giving rise to a heterogeneous directed graph. We study the dynamics of the networks thus obtained, along with their topology (using degree distributions). Some considerations are made about the biological meaning of the outcome of the simulations.

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