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Medical Cannabis in the Treatment of Epilepsy
Abstract
Epilepsy is one of the most known neurological diseases of therapeutic challenge. Medical marijuana/medicinal cannabis is a cannabinoid phytochemical derivative of the cannabis plant used for medical purposes in treating seizures and has increased sharply in current years. Cannabis plants contain over 100 cannabinoids, and evidence supports its practice in the treatment of a few childhood epilepsies. The active and major cannabinoids such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) exist in the cannabis plant and are the topic of the present study. Cannabinoids' biological activities are facilitated by their interaction with two similar receptors, cannabinoid receptor type 1 (CB1) and type 2 (CB2), as well as a wide range of other receptors and targets implicated in the effects of these compounds. The review will focus on the effectiveness and challenges of cannabinoids in treating epilepsy.
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