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Glial Cells Dysfunction and Chronic Pain
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Author(s): Hafida El Ghachi (Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco), Asmaa Haj-khlifa (Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco), Mjid Oukhrib (Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco), Lahcen Tamegart (Faculty of Sciences, Abdelmalek Essaadi University, Morocco), Youssef Ait Hamdan (Higher Normal School, Cadi Ayyad University, Morocco), Abdelali Ben Maloui (Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco), Najib Kissani (Department of Neurology, Medical Research Center, University Hospital Mohamed VI, Morocco)and Halima Gamrani (Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco)
Copyright: 2024
Pages: 25
Source title:
Physiology and Function of Glial Cells in Health and Disease
Source Author(s)/Editor(s): Bilal El-Mansoury (Faculty of Sciences, Chouaib Doukkali University, Morocco), Omar El Hiba (Chouaib Doukkali University, Morocco)and Arumugam Radhakrishnan Jayakumar (University of Miami, USA)
DOI: 10.4018/978-1-6684-9675-6.ch007
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Abstract
Chronic pain is a pathological health condition caused by the imbalance between inhibitory and excitatory signaling pain pathways. This clinical problem affects about 30% of adults worldwide, and current treatments are insufficient with side effects. The mechanisms underlying this disease were thought to be a result of neuronal dysfunction, however, several animal studies clearly showed that non-neuronal cells (glial cells), primarily microglia and astrocytes, and their interaction with neurons, had a key role in pain persistence. A long-lasting state of activated glia turns to a pathological element causing a painful sensation. This chapter aims to elucidate glial dysfunction by shedding light on peripheral and central glial cells involved in the pathogenesis of chronic pain.
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