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Gene Drug Delivery for the Treatment of Cancer
Abstract
Gene drug delivery is a pivotal approach in modern cancer treatment, offering targeted therapies that overcome the limitations of conventional methods. This chapter delves into the significance of gene therapy in oncology, highlighting key mechanisms like gene silencing, suicide genes, and tumor suppressor gene replacement to inhibit cancer progression. Advanced delivery systems are essential for effective gene therapy. The chapter explores nanocarriers and both viral and nonviral gene delivery methods as critical tools for improving precision. Gene editing technologies like CRISPR-Cas9 are also investigated for their potential to transform treatment. The integration of gene therapy with other modalities, such as immunotherapy and personalized medicine, is proposed as a way to improve patient outcomes. Future directions and developing trends in gene therapy, including innovations in delivery technologies and the persistent obstacles in clinical translation, are also explored. This chapter offers a concise overview of the current and future prospects of gene therapy in cancer treatment.
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