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Environmental DNA and RNA Metabarcoding: Advancing Insights in Cancer Research
Abstract
Environmental DNA (eDNA) and RNA (eRNA) technologies, when integrated with metabarcoding, have emerged as significant instruments in cancer research particularly in exposomics and environmental carcinogenesis. These approaches facilitate the identification and monitoring of genetic material from many environmental sources, yielding insights into the biological and chemical factors that influence cancer risk. Environmental samples can be examined to identify pollutants, microbiota, and other molecular markers that contribute to carcinogenesis through the use of eDNA and eRNA. Metabarcoding enhances this technique by employing high-throughput sequencing to facilitate the comprehensive characterisation of complex ecosystems, the detection of potential carcinogenic exposures, and the elucidation of their interactions with human health. This methodology possesses significant potential for enhancing our comprehension of the environmental factors associated with early detection, prevention, and treatments. This chapter explores the concept of the human exposome as evidenced by eDNA and eRNA.
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