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Cutting-Edge in Vitro Models and Multi-Omics Approaches for Carcinogen Exposome Studies
Abstract
The exposome concept has complemented the genome by opening new areas for cancer research. The in vitro models used in this context are fundamental for unraveling the molecular and cellular effects of carcinogenic agents in a controlled environment. Moreover, these models offer a new possibility for investigating the key mechanisms of tumor initiation and progression, bridging the gap between epidemiological data and mechanistic studies. In the same way, integrating recent technologies such as multiomics (genomics, transcriptomics, proteomics, metabolomics, etc.) expands the horizon for a deep understanding of cellular responses to carcinogenic exposures. This chapter reviews recent cutting-edge advances in using experimentation models to study the carcinogenic exposome. It emphasizes their role in understanding carcinogenesis pathways, focusing on the most up-to-date technologies.
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