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Current Update on Natural Agents Against Triple Negative Breast Cancer
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Author(s): Prathibha Sivaprakasam (B. S. Abdur Rahman Crescent Institute of Science and Technology, India), Sureshkumar Anandasadagopan (Central Leather Research Institute, India), Tamilselvi Alagumuthu (Central Leather Research Institute, India)and Ashok Kumar Pandurangan (B.S. Abdur Rahman Crescent Institute of Science and Technology, India)
Copyright: 2020
Pages: 23
Source title:
Advanced Pharmacological Uses of Medicinal Plants and Natural Products
Source Author(s)/Editor(s): Ajeet Singh (National Dairy Research Institute, India), Padam Singh (Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, India)and Navneet Bithel (Gurukul Kangri University, India)
DOI: 10.4018/978-1-7998-2094-9.ch005
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Abstract
Breast cancer (BC) is sub-categorized into several well-recognized subtypes including estrogen receptor (ER), progesterone receptor (PR), and HER2 triple-negative breast cancer (TNBC). It is a heterogeneous disease entity constituting about 15% of breast cancer cases worldwide. TNBC is associated with poor prognosis and lack of sustained response to conventional chemotherapeutic agents. Although no approved targeted therapy is available for TNBCs, molecular-profiling efforts have revealed promising molecular targets such as the Wnt/β-catenin, STAT3, VEGF, EGFR, polyadenosine ribose polymerase inhibitors (PARPi) and DNA repair pathway, androgen pathway, and NOTCH pathway. Moreover, more research needs to be performed in the area of TNBC aiming at dissecting potential pathways and identifying potential molecular signatures to develop new targeted biologic modifiers. Natural agents are the abundant chemical compounds available from diverse plants. The authors aimed to summarize the current evidence and discuss the natural agents that target TNBC using different pathways.
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