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Construction and Analysis of Protein-Protein Interaction Network: Role in Identification of Key Signaling Molecules Involved in a Disease Pathway
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Author(s): Divya Dasagrandhi (Bharathidasan University, India), Arul Salomee Kamalabai Ravindran (Bharathidasan University, India), Anusuyadevi Muthuswamy (Bharathidasan University, India)and Jayachandran K. S. (Bharathidasan University, India)
Copyright: 2019
Pages: 17
Source title:
Computer Applications in Drug Discovery and Development
Source Author(s)/Editor(s): A. Puratchikody (Anna University, India), S. Lakshmana Prabu (Anna University, India)and A. Umamaheswari (Anna University, India)
DOI: 10.4018/978-1-5225-7326-5.ch009
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Abstract
Understanding the mechanisms of a disease is highly complicated due to the complex pathways involved in the disease progression. Despite several decades of research, the occurrence and prognosis of the diseases is not completely understood even with high throughput experiments like DNA microarray and next-generation sequencing. This is due to challenges in analysis of huge data sets. Systems biology is one of the major divisions of bioinformatics and has laid cutting edge techniques for the better understanding of these pathways. Construction of protein-protein interaction network (PPIN) guides the modern scientists to identify vital proteins through protein-protein interaction network, which facilitates the identification of new drug target and associated proteins. The chapter is focused on PPI databases, construction of PPINs, and its analysis.
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