Computational Investigation of Versatile Activity of Piperine

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Author(s): Thenmozhi Marudhadurai (Selvam College of Technology, India)and Navabshan Irfan (Anna University, India)
Copyright: 2019
Pages: 13
Source title: Computer Applications in Drug Discovery and Development
Source Author(s)/Editor(s): A. Puratchikody (Anna University, India), S. Lakshmana Prabu (Anna University, India)and A. Umamaheswari (Anna University, India)
DOI: 10.4018/978-1-5225-7326-5.ch006

Keywords: Medical Information Science Reference / Medical Technologies / Medicine & Healthcare

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Abstract

Piperine is known for its versatile therapeutic activity. It has been used for various disease conditions (e.g., cold, cough, etc.). Piperine is an alkaloid found in black pepper. It possesses various pharmacological actions like anti-inflammatory, anti-oxidant, anti-cholinergic, and anti-cancerous. The above-mentioned properties will be studied by selecting target proteins COX-2 protein, angiotensin converting enzyme, acetylcholineesterases, and survivin using computational docking study. This chapter explains the inhibition property of piperine against selected target protein from the results of docking studies. Based on the docking scores and protein-ligand interactions, piperine was found to bind well in the active site of the selected target proteins. It ensures the binding efficacy of piperine against selected target proteins. Docking scores and protein-ligand interactions plays an important role in its therapeutic activity.

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