Biomolecular Computing Devices in Synthetic Biology

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Author(s): Jesús M. Miró (Universidad Politécnica de Madrid (UPM), Spain)and Alfonso Rodríguez-Patón (Universidad Politécnica de Madrid (UPM), Spain)
Copyright: 2009
Pages: 18
Source title: Advancing Artificial Intelligence through Biological Process Applications
Source Author(s)/Editor(s): Ana B. Porto Pazos (Coruna University, Spain), Alejandro Pazos Sierra (Coruna University, Spain)and Washington Buño Buceta (Cajal Institute, Spanish Council for Scientific Research, Spain)
DOI: 10.4018/978-1-59904-996-0.ch014

Keywords: Bioinformatics / Biologically-Inspired Computing / Medical Information Science Reference / Medicine & Healthcare

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Abstract

Synthetic biology and biomolecular computation are disciplines that fuse when it comes to designing and building information processing devices. In this chapter, we study several devices that are representative of this fusion. These are three gene circuits implementing logic gates, a DNA nanodevice and a biomolecular automaton. The operation of these devices is based on gene expression regulation, the so-called competitive hybridization and the workings of certain biomolecules like restriction enzymes or regulatory proteins. Synthetic biology, biomolecular computation, systems biology and standard molecular biology concepts are also defined to give a better understanding of the chapter. The aim is to acquaint readers with these biomolecular devices born of the marriage between synthetic biology and biomolecular computation.

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