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Antidiabetic Activity (Anti-Hyperglycemic Activity, Anti-Hyperlipidemic Activity)/Agents From Medicinal Plants
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Author(s): Manish Singh Sansi (National Dairy Research Institute, India), Daraksha Iram (National Dairy Research Institute, India), Kapil Singh Narayan (National Dairy Research Institute, India), Sandeep Kumar (National Dairy Research Institute, India), Om Prakash (National Dairy Research Institute, India)and Dipanjan Misra (National Dairy Research Institute, India)
Copyright: 2020
Pages: 24
Source title:
Advanced Pharmacological Uses of Medicinal Plants and Natural Products
Source Author(s)/Editor(s): Ajeet Singh (National Dairy Research Institute, India), Padam Singh (Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, India)and Navneet Bithel (Gurukul Kangri University, India)
DOI: 10.4018/978-1-7998-2094-9.ch002
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Abstract
Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased insulin secretion by the organ. Insulin deficiency causes the DM. Synthetic drugs are widely used in the treatment of diabetes, but they have some side effects. The antihyperglycemic and antihyperlipedemic effects of the plants are related to their ability to maintain pancreatic function. Medicinal plants constituents such as glycosides, alkaloids, terpenoids, and flavonoids mitigate DM. B. ciliata inhibits the α-glucosidase and α-amylase. Cinnamon extracts improve insulin receptor function by activating insulin receptor kinase and inhibiting insulin receptor phosphatase, which lead to an increase in insulin sensitivity. Morinda lucida also had the highest antioxidant activity, and it also inhibited the α-glucosidase. Many plants have also been shown to antihyperlipedemic effects. Finally, it can be concluded that medicinal plants have that ability to treat or prevent DM.
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