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Anti-Tumor Effects of Cannabinoids in Brain, Lung, Breast, Prostate, Colorectal, and Pancreatic Cancers: A Systematic Review of the Literature
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Author(s): Dhairavi Shah (Kean University, USA), Dhaara Shah (Kean University, USA), Yara Mohamed (Kean University, USA), Danna Rosas (Kean University, USA), Alyssa Moffitt (Kean University, USA), Theresa Hearn Haynes (Saint James School of Medicine, USA), Francis Cortes (Saint James School of Medicine, USA), Taunjah Bell Neasman (Saint James School of Medicine, USA), Phani kumar Kathari (Saint James School of Medicine, USA), Ana Villagran (Kean University, USA)and Rana R. Zeine (Kean University, USA)
Copyright: 2023
Pages: 28
Source title:
Medical Cannabis and the Effects of Cannabinoids on Fighting Cancer, Multiple Sclerosis, Epilepsy, Parkinson's, and Other Neurodegenerative Diseases
Source Author(s)/Editor(s): Rana R. Zeine (Kean University, USA)and Brian W. Teasdale (Kean University, USA)
DOI: 10.4018/978-1-6684-5652-1.ch005
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Abstract
In search for new cancer treatments, the anti-tumor effects of cannabinoids are under investigation. This study systematically reviews the experimental and clinical evidence for benefits of cannabinoids in cancer. Literature search was conducted through PubMed, EBSCO Host, and ProQuest electronic databases. The text words “medical marijuana,” “cannabis,” “cannabinoids,” “cannabidiol (CBD),” and “Δ9-Tetrahydrocannabinol (THC),” with the Boolean operator “AND” “cancer” either “brain,” “lung,” “breast,” “prostate,” “colorectal,” or “pancreatic” were used to identify studies on anti-tumor effects of cannabinoids. Treatment with cannabinoids decreased cell proliferation, tumor size, angiogenesis, adhesion, migration, and metastasis, and promoted cell cycle arrest, apoptosis, and autophagy in tumor cells and xenograft models and overall survival in cancer patients. There is strong experimental evidence for anti-tumor effects of cannabinoids. Clinical trials are warranted, and further experimental studies are needed to elucidate the pharmacologic potential for cannabinoids in oncology.
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