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Aging and Reactive Oxygen Species Implications for Cellular Senescence and Longevity: Oxygen Toxicity and Aging
Abstract
Aging, a substantial cause of physical and psychosocial degradation, is attaining a significant public health concern with passage of time. It is characterized by progressive loss and delayed response of the body system followed by development of systemic complications. It enhances financial burden to the health care system. Compounding the evidences from previous reports, enhanced free radicals production mediated chronic oxidative stress along with aging process has been attributed as a specific and critical component to the etiopathology of various health complications. Many of the recommended interventions present only symptom-modifying effects, and a few structure-modifying effects. Thus, the present chapter aims to provide a narrative review on mystery of aging process by highlighting the complex interplay of oxidative and inflammatory stress, and orchestrate a repertoire of novel therapeutic strategies to get rid of curse of senescence.
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