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Reactive Oxygen Species: Generation and Signaling Pathways
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Author(s): Anam Khan (Department of Biochemistry, AIl India Institute of Medical Sciences Bhopal, India & Department of Biotechnology, Barkatullah University, Bhopal, India), Ragini Gothalwal (Department of Biotechnology, Barkatullah University, Bhopal, India)and Ashwin Kotnis (Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, India)
Copyright: 2025
Pages: 42
Source title:
The Role of Reactive Oxygen Species in Human Health and Disease
Source Author(s)/Editor(s): Pranav Kumar Prabhakar (Department of Biotechnology, Nagaland University, India)
DOI: 10.4018/979-8-3693-7919-6.ch001
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Abstract
Reactive oxygen species (ROS) are highly reactive molecules that are constantly generated as natural byproducts of cellular metabolism. While traditionally considered detrimental due to their potential to cause oxidative damage, recent research has unveiled their intricate involvement in cellular signaling pathways. This book chapter provides a comprehensive overview of ROS generation mechanisms, encompassing enzymatic and non-enzymatic processes and their pivotal roles in redox signaling pathways. Additionally, it delves into the various functions of reactive oxygen species (ROS) in cellular signaling, highlighting their influence on redox balance, gene expression, and stress reactions. This chapter tries to establish the foundation for understanding ROS biology and their intricate functions in both health and illness by clarifying some basic concepts.
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