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Novel Advancements in Genome Editing Technology to Be Used in In vitro fertilization (IVF)

Novel Advancements in Genome Editing Technology to Be Used in In vitro fertilization (IVF)
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Author(s): Bhakti Shrinivas Pulla (Symbiosis International University (Deemed), Pune, India), Vibha Pote (Symbiosis Institute of Health Sciences, Symbiosis International University (Deemed), Pune, India)and Samruddhi Dhulkhedkar (Symbiosis Institute of Health Sciences, Symbiosis International University (Deemed), Pune, India)
Copyright: 2024
Pages: 24
Source title: Green AI-Powered Intelligent Systems for Disease Prognosis
Source Author(s)/Editor(s): Ashish Khanna (Maharaja Agrasen Institute of Technology, India)and Saikat Gochhait (Symbiosis Institute of Digital and Telecom Management, Symbiosis International (Deemed), India & Samara State Medical University, Russia)
DOI: 10.4018/979-8-3693-1243-8.ch017

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Abstract

Genome editing in human embryos has raised keen concern worldwide. Genome editing might be acceptable in limited cases of serious or life-threatening conditions, where no alternative medicine is available. New methods of in vitro fertilization and the vastly expanding number of diseases are the reasons for preimplantation genetic diagnosis (PGD) testing. In recent years, cutting-edge genetic analysis methods have been applied in therapeutic settings. Promising techniques include blastocyst-stage biopsy, vitrification, time-lapse imaging, whole-genome amplification, array-based diagnostics, CRISPR-Cas 19, and next-generation sequencing for the accurate diagnosis of a variety of genetic conditions as well as for the selection of the best embryo with the best genetic potential. The 'genetic scissors' are easier to engineer, more efficient in methodology, and more precise in genome sequence being targeted. During in vitro fertilization (IVF) cycles, preimplantation genetic diagnosis/screening (PGD/PGS) tries to assist couples in reducing the risks of passing genetic abnormalities to their offspring, implantation failure, and/or miscarriage. The very novel techniques for base gene editing, protein synthesis, RNA editing systems, genomic data storage systems, and the building of bio parts have been revolutionised with the application of virtual screening till the date. Artificial intelligence would overtake the manpower and man skills put forth at the scientific laboratory if used precisely which would further bring a huge progress and advancement in synthetic biology. Hence, this study aims to review and study the novel technologies used for gene editing which would work with the application of artificial intelligence with accuracy and preciseness leading to better embryo development.

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